杜金志 研究员
智能纳米医学实验室
华南理工大学博士生导师
国家优秀青年科学基金获得者
广东省杰出青年基金获得者
广东省珠江人才计划青年拔尖人才
Email：djzhi@scut.edu.cn
招生方向
高分子化学、生物学、生物医学工程、药学
教育/工作经历
2016.10-至今，华南理工大学，医土耳其里拉兑换人民币、生命科学研究院，研究员
2012.05-2016.08，美国埃默里大学（Emory University）医土耳其里拉兑换人民币，博士后
2006.09-2011.12，中国科学技术大学，高分子化学与物理，博士
2002.09-2006.07，中国科学技术大学，高分子化学，学士
研究概述
实验室主要研究兴趣包括生物医用材料、药物载体与递送、肿瘤免疫治疗等，是材料学、生命科学和医学等多学科交叉的方向。课题组的研究以解决医学、生命科学等临床或科学问题为出发点，综合运用材料学、纳米技术等技术手段，设计开发新型生物医用材料，深入探究其在癌症、自身免疫性疾病等治疗方面的应用。
科研成果
近年来在Acc Chem Res、PNAS、JACS、Angew Chem Int Ed、ACS Nano、Nano Lett等国际知名期刊发表SCI论文40余篇，他引4000余次，单篇最高他引近800次，6篇论文入选ESI高被引，2篇入选研究前沿。研究成果入选2019年中国生物材料学会科学技术奖二等奖。申请中国发明专利5项，其中2项获得授权；受邀参与编写英文专著1章。主持基金委优秀青年基金、面上项目、广东省杰出青年基金，参与国家重点研发计划、广东省“珠江人才计划”创新团队等项目。目前担任中国抗癌协会纳米肿瘤学专业委员会青年委员、中国生物工程学会纳米医学与工程分会青年委员。
代表性研究论文
1. Jia-Xian Li#, Qiu-Yue Huang#, Jing-Yang Zhang, Jin-Zhi Du*, Engineering nanoparticles to tackle tumor barriers. Journal of Materials Chemistry B, 2020, DOI: 10.1039/D0TB00967A (2020 Emerging Young Investigator Special Issue)
2. Ya-Ru Zhang, Jia-Qi Luo, Jia-Xian Li, Qiu-Yue Huang, Xiao-Xiao Shi, Yong-Cong Huang, Kam Leong, Wei-ling He*, Jin-Zhi Du*, Biofunctional Janus particles promote phagocytosis of tumor cells by macrophages. Chemical Science, 2020, 11, 5323-5327
3. Hong-Jun Li#, Jing Liu#, Ying-Li Luo, Sen-Biao Chen, Rong Liu, Jin-Zhi Du*, Jun Wang*, Intratumor performance and therapeutic efficacy of PAMAM dendrimers carried by clustered nanoparticles, Nano Lett. 2019, 19, 8947-8955.
4. Jing Liu, Hong-Jun Li*, Ying-Li Luo, Cong-Fei Xu, Xiao-Jiao Du, Jin-Zhi Du*, Jun Wang Enhanced Primary Tumor Penetration Facilitates Nanoparticle Draining into Lymph Nodes after Systemic Injection for Tumor Metastasis Inhibition ACS Nano 2019, 13, 8648?8658.
5. Jin-Zhi Du*, Hong-Jun Li, Jun Wang*, Tumor-acidity cleavable maleic acid amide (TACMAA): a powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine Acc. Chem. Res. 2018, 51, 2848?2856.
6. Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy Nano Lett. 2017, 17, 3822–3829
7. Hong-Jun Li#, Jin-Zhi Du*,#, Jing Liu, Xiao-Jiao Du, Song Shen, Yan-Hua Zhu, Xiaoyan Wang, Xiaodong Ye, Shuming Nie*, Jun Wang*, Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration ACS Nano 2016, 10, 6753–6761
8. Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anti-Cancer Drug Delivery J. Am. Chem. Soc. 2011, 133, 17560–17563
9. Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery Angew. Chem. Int. Ed. 2010, 49, 3621–3626
10. Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shuming Nie*, Jun Wang*, Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 4164–4169
11. Jinzhi Du, Lucas A. Lane, Shuming Nie*, Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment J. Controlled Release 2015, 219, 205–214
论文详细列表：
http://www.researcherid.com/rid/F-8453-2010
https://scholar.google.com/citations?user=x9sswP8AAAAJ&hl=en