报告题目一：3D打印生物材料用于骨修复与治疗：物理、化学、免疫调节到多功能
报告人：吴成铁教授
报告摘要：
For therapy and regeneration of bone defects resulting from malignant bone disease, it is of great importance to develop multifunctional biomaterials for bone therapy and regeneration. Conventional biomaterials always lack multifunctional properties, limiting their application for treating and repairing bone disease (e.g. bone tumors)-initiated defects. How to design and prepare bioscaffolds with favorable microenvironments for disease therapy and tissue regeneration is one of interesting topics in the fields of biomaterials and tissue engineering. We developed several strategies, including harnessing nutrient elements, biomimetic structure and functional interface as well as thermo-therapy to construct multifunctional scaffolds by 3D-Pringting method for therapy and regeneration of bone tissues. It is interesting to find that both nutrient elements and biomimetic structure of the printed bioscaffolds have important effect on the stimulation of osteogenesis and angiogenesis of stem cells, and thermotherapy plays an important role to treat bone tumors. Therefore, we put forward new concept that 3D-Printed bioscaffolds combined bone therapy and regeneration could be a new direction of bone tissue engineering.
报告题目二：Functional biomaterials for regenerative medicine（功能生物材料及其于再生医学领域的应用）
报告人：边黎明博士
报告摘要：
Diseases and injuries in the musculoskeletal systems such as osteoarthritis (OA), non-union bone fracture, and ligament tears have become an increasingly serious health problem among the aging populations in modern societies. In recent years, human mesenchymal stem cells (hMSCs) have gained popularity as a cell source for the repair and regeneration of the musculoskeletal tissues. However, there is still a lack of functional biomaterial carriers to aid the translation of stem cells to clinical applications. In the most recent decade, increasing research emphasis has been placed on the biological and physical functionality of the biomaterials. Rather than being biologically inert, novel biomimetic biomaterials with intricate biological functions which can proactively interact with living cells and tissues by design have been presented by a number of recent studies. Furthermore, biomaterials of superior physical properties such as mechanical robustness and injectability are also required to effectively support the implanted stem cells and to enhance the outcomes of the stem cell therapies. In this seminar, I will talk about our recent research work on the functionalization of the hydrogels with biomimetic peptides to promote the differentiation of the hMSCs. In addition to the biofunctionalization, the physical functions of the biomaterials are also critical to the successful translation of biomaterials to clinical treatment of musculoskeletal tissue injuries. We have developed a series of injectable hydrogels with unique properties such as resilient mechanical property, bioadhesiveness, injectability, and promoting recruitment of endogenous cells that are desirable for potential clinical applications in treating musculoskeletal injuries and degenerations.
时间：2016年3月31日（星期四）上午9：30
地点：大学城校区B12-410会议室
附报告人简介：
吴成铁：博士生导师、中科院百人计划、德国洪堡学者、上海市优秀学科带头人和上海市浦江人才计划获得者。现任中科院上海硅酸盐研究所生物材料与组织工程研究中心副主任，澳大利亚昆士兰科技大学客座教授、中国医师协会骨科再生医学工作组副主席、中国生物医学工程学会组织工程与再生医学分会委员、中国生物医学工程协会青年工作委员会委员等；学术期刊“Applied Materials Today”与“Biomedical Glasses”副主编，“Progress in Natural Science: Materials International”等杂志编委。2006年初博士毕业于中科院上海硅酸盐研究所后，先后在澳大利亚悉尼大学、昆士兰科技大学及德国德累斯顿工业大学从事研究工作6年。主要从事3D打印生物活性无机材料用于硬组织修复材料的研究。2011年底获得中国科土耳其里拉兑换人民币上海硅酸盐研究所海外杰出人才（中科院百人计划）引进，应聘回国从事科研工作。在国外先后获得德国洪堡学者、澳大利亚ARC研究员（APDI）、悉尼大学研究员及昆士兰科技大学研究员等四个荣誉研究员（Fellowship）。主编CRC英文专著《Advanced bioactive inorganic materials for bone regeneration and drug delivery》一部，并参与撰写5本英文专著的章节；在生物材料相关领域发表SCI 期刊论文140多篇，主要包括Mater Today, AdvFunct Mater （2篇）, Chem Science, Biomaterials（16篇），Small, J Control Release, ActaBiomater(26篇),Bone等。论文共被SCI引用3500余次，h指数35，入选Elsevier评选2015中国高引用学者榜单（生物医学工程第3位）；共申请专利15项，获5项中国专利及2项美国专利授权，其中2项中国专利与1项美国专利已经转让公司。
边黎明：博士，助理教授。生物医学工程部，机械与自动化工程系，香港中文大学。边教授分别与 2002 年及2004 年在新加坡国立大学获得本科学士及生物工程硕士学位，2004 年赴美哥伦比亚大德赢新版app物医学工程学系继续攻读博士学位。2009 年获博士学位后，在宾夕法尼亚大德赢新版app物工程学系进行博士后研究。2012 年夏开始就职于香港中文大学。边教授研究的主要方向是生物支架材料的设计及在干细胞组织工程方面的应用。具体的研究方向有仿生生物材料，高性能水凝胶，多功能纳米生物材料，细胞微环境信号，干细胞软骨组织工程等。边教授的科研成果发表在“PNAS”，“Biomaterials”，”JACS”, “Nano Letters”,“Macromolecules”，“Adv Functional Materials”，“AdvHealthcare Materials”,“Tissue Engineering Part A”等学术期刊杂志。