报告题目：C–C activation of unstrained substrates: from ketones to amides
报告人：芝加哥大学张睿博士
邀请人：吴钊教授
时间：2024年3月4日（周一）上午10:30
地点：广州国际校区C3-c204 （腾讯会议：243-642-574）
前沿软物质土耳其里拉兑换人民币
华南软物质科学与技术高等研究院
2024年2月28日
报告摘要:
C–C activation reactions have attracted significant interest in the past decades due to their efficiency in constructing or editing complex molecular backbones. Current C–C activation transformations mainly include strained rings, pre-aromatized intermediates, forming strong M–CN bonds or β-scission to give stable products. These requirements in substrate patterns largely limit their further applications. Therefore, novel strategies to selective activate C–C bonds in more general substrates are still highly sought after. In this seminar, I will introduce my work on the strategic manipulation of C–C bonds in unstrained ketones and amides. With rationally designed activation reagents and ligands, we achieved the efficient structural editing for general ketones and amides, including annulation, homologation, and ring contraction. These transformations offer new strategies for chemical synthesis and broaden the space for derivatization of bioactive molecules.
报告人简介:
张睿博士，2019年本科毕业于北京大学，师从王剑波教授。2019 -2024年在芝加哥大学董广彬教授课题组攻读博士学位，主要研究方向是过渡金属催化的非张力底物碳碳键活化。迄今已在Science, Nat. Chem., Angew. Chem. Int. Ed. 等国际期刊以第一作者或共同第一作者身份发表研究成果。曾获得Alfred R. Bader Award（2021）和百时美施贵宝奖学金（2022）。
